The best gaming mouse with side buttons can move frequently used commands from the keyboard to your thumb, making it easier to manage abilities, macros, push-to-talk, and everyday shortcuts.
This roundup compares 10 options across wired and wireless designs, compact control layouts, MMO-focused button grids, sensor resolution, battery life, and customization software so you can choose the right fit for your games and grip.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
Best Overall
Logitech G502 HERO Wired Gaming Mouse
- 11 programmable buttons
- 25,600 DPI HERO sensor
- Adjustable weight system
Best For: Right-handed PC gamers wanting customizable wired control
Best MMO Value
Redragon M901P-KS Wireless MMO Mouse
- 12 remappable side buttons
- 16 programmable controls
- 70-plus-hour rechargeable battery
Best For: MMO players needing many wireless hotkeys
Best Battery Life
Razer Naga V2 HyperSpeed Wireless MMO Mouse
- 19 programmable buttons
- Up to 400 hours on Bluetooth
- 2.4GHz and Bluetooth connectivity
Best For: Wireless MMO gamers seeking long battery life
Best Budget Wired Pick
- 11 remappable buttons
- Up to 8,000 DPI
- Ergonomic grip with RGB modes
Best For: Gamers wanting affordable wired customization
Most Versatile
Razer Naga V3 Pro Wireless MMO Gaming Mouse
- Three swappable side-plate layouts
- Wireless, Bluetooth, and USB-C modes
- Up to 280 hours of Bluetooth battery life
Best For: Players switching between MMO, MOBA, FPS, and everyday tasks
Best Wired Value
Redragon M908 MMO Gaming Mouse
- 18 programmable buttons with 12 on the side
- Five memory profiles and RGB lighting
- Includes adjustable weight set
Best For: Budget-focused MMO players who prefer wired control
Best for Streaming
Corsair Scimitar Elite Wireless SE
- 16 programmable buttons
- Native Elgato Stream Deck integration
- Up to 150 hours of battery life
Best For: MMO and MOBA players who stream or use Elgato tools
Maximum MMO Control
- 12 programmable side buttons for MMO keybinds
- 16,400 DPI with adjustable sensitivity
- Adjustable weights and five custom profiles
Best For: MMO players needing extensive wired customization
Flexible Wireless MMO Play
Redragon M913 Wireless MMO Mouse
- Wireless and USB-C wired modes
- 12 side buttons with 16 programmable inputs
- Up to 45 hours with RGB or 80 hours in eco mode
Best For: MMO gamers wanting wireless convenience and wired backup
Streamlined MMO Keybinds
- Eight MMO side buttons and 15 programmable controls
- Software-adjustable DPI from 500 to 12,400
- Ergonomic wired design for extended use
Best For: Gamers wanting strong keybinding without a 12-button grid
Best Overall – Logitech G502 HERO Wired Gaming Mouse
The Logitech G502 HERO is a strong all-around gaming mouse with side buttons for players who want precise wired performance and extensive customization. Its 11 programmable buttons, adjustable weights, high-resolution sensor, and dual-mode scroll wheel cover a wide range of games.
Best For: Right-handed PC gamers who prefer a customizable wired mouse with adjustable balance.
Pros:
- 11 programmable buttons provide flexible control for games and productivity.
- HERO sensor supports tracking up to 25,600 DPI without smoothing, filtering, or acceleration.
- Five removable 3.6 g weights let you adjust balance and feel.
- LIGHTSYNC RGB and mechanical button tensioning add customization and crisp click feedback.
Cons:
- Wired design does not offer wireless freedom.
- Right-handed shape limits its suitability for left-handed users.
The G502 HERO is a versatile choice when dependable wired tracking and a substantial set of programmable controls matter more than a lightweight design.
Best MMO Value – Redragon M901P-KS Wireless MMO Mouse
The Redragon M901P-KS is a gaming mouse with side buttons aimed at MMO and strategy players who need many commands close at hand. It combines 12 remappable side buttons with wireless operation, onboard profiles, RGB lighting, and a rechargeable battery.
Best For: Right-handed MMO players who want extensive button mapping without staying tethered to a cable.
Pros:
- 16 programmable buttons include 12 dedicated side buttons.
- Five memory profiles and two working modes support different games or tasks.
- Rechargeable 1,000mAh battery provides over 70 hours with RGB turned off.
- Adjustable DPI from 100 to 16,000 and polling rates from 125Hz to 1,000Hz.
Cons:
- Its large button count may require an adjustment period.
- Battery life is specified with RGB lighting off.
- Right-handed design is not intended for left-handed use.
With its unusually large side-button grid and wireless flexibility, the M901P-KS is particularly practical for MMO hotkeys and other command-heavy setups.
Best Battery Life – Razer Naga V2 HyperSpeed Wireless MMO Mouse
The Razer Naga V2 HyperSpeed is a gaming mouse with side buttons for players who want a broad command set without frequent battery changes. It offers 19 programmable buttons, low-latency 2.4GHz wireless, Bluetooth, and a battery rated for up to 400 hours in Bluetooth mode.
Best For: Right-handed MMO gamers who prioritize wireless endurance and extensive programmable controls.
Pros:
- 19 programmable buttons provide a large command capacity.
- Up to 400 hours of Bluetooth battery life or 250 hours over HyperSpeed wireless.
- Focus Pro 30K optical sensor is designed to track across a wide range of surfaces, including glass.
- HyperScroll supports free-spin and tactile scrolling modes.
Cons:
- Requires a single AA battery rather than using a built-in rechargeable battery.
- Right-handed shape limits ambidextrous use.
- Its many programmable buttons may be more than casual players need.
The Naga V2 HyperSpeed stands out for combining a high button count with exceptional stated battery life, making it a strong option for long wireless gaming sessions.
Best Budget Wired Pick – Redragon M612 Predator
The Redragon M612 Predator is an accessible gaming mouse with side buttons for players who want configurable controls and RGB lighting at a straightforward wired setup. It provides 11 programmable buttons, adjustable DPI settings, macro functions, and an ergonomic claw-grip design.
Best For: PC or Mac gamers who want programmable side controls and a comfortable wired mouse for gaming and everyday use.
Pros:
- All 11 buttons can be reassigned through software.
- Two side macro buttons and a rapid-fire key add extra control options.
- DPI can be adjusted from 500 to 8,000, with five preset levels.
- Frosted coating, textured side grip, and five RGB backlight modes support comfort and customization.
Cons:
- Wired connectivity lacks the freedom of a wireless mouse.
- Its 8,000 DPI maximum is lower than the other listed options.
- Only two side macro buttons are specifically identified.
The M612 Predator makes sense for buyers who need useful remapping and side controls without moving to a more complex MMO-focused mouse.
Most Versatile – Razer Naga V3 Pro Wireless MMO Gaming Mouse
The Razer Naga V3 Pro is a highly adaptable gaming mouse with side buttons, thanks to its three swappable plates. Choose a 12-, 6-, or 2-button layout for MMO, MOBA, FPS, or battle royale play, then customize controls in Razer Synapse.
Best For: Players who want one wireless mouse for multiple game genres and productivity tasks.
Pros:
- Three magnetic side-plate layouts support different games.
- HyperSpeed wireless, Bluetooth, and USB-C wired connectivity.
- Up to 155 hours of HyperSpeed or 280 hours of Bluetooth battery life.
- 50K DPI optical sensor and optical switches rated for over 100 million clicks.
Cons:
- Full customization is available on Windows, while macOS is limited to core functions and onboard settings.
- Wireless charging accessories are sold separately.
Its interchangeable side-button system makes the Naga V3 Pro a strong choice if your control needs change from game to game. It is especially compelling for MMO players who also want a lighter button layout for shooters.
Best Wired Value – Redragon M908 MMO Gaming Mouse
The Redragon M908 is a wired gaming mouse with side buttons built around extensive remapping. It provides 12 MMO side buttons within an 18-button design, along with adjustable DPI, onboard profiles, RGB lighting, and a weight-tuning set.
Best For: Budget-conscious MMO players who prefer a wired mouse with many programmable controls.
Pros:
- 18 programmable buttons, including 12 side buttons.
- Five memory profiles help organize different control setups.
- Adjustable sensitivity reaches up to 12,400 DPI.
- Includes eight removable 2.4-gram weights and a braided 6-foot cable.
Cons:
- USB wired operation does not provide wireless flexibility.
- Programmable features are intended for Windows; Mac is listed for normal use.
- At 175 grams, it is a relatively heavy mouse.
The M908 focuses on button quantity and customization rather than wireless convenience. Its adjustable weight system and profile storage make it a practical pick for MMO users who want substantial control at a typically approachable feature set.
Best for Streaming – Corsair Scimitar Elite Wireless SE
The Corsair Scimitar Elite Wireless SE is a wireless gaming mouse with side buttons that combines 16 programmable controls with Elgato Stream Deck integration. Its 33K DPI sensor, 1,000Hz SLIPSTREAM wireless connection, Bluetooth, and USB charging support gaming, streaming, and productivity.
Best For: MMO or MOBA players who also stream and want mouse buttons tied to Elgato functions.
Pros:
- 16 programmable buttons provide dedicated access to abilities and actions.
- Native and virtual Elgato Stream Deck integration expands button functionality.
- SLIPSTREAM wireless offers low-latency performance with 1,000Hz polling.
- Supports wireless, Bluetooth, and USB connections with up to 150 hours of battery life.
Cons:
- Requires Windows 11 or macOS 14 Sonoma according to the listed requirements.
- Its feature set may be more than needed for players who do not stream or use Elgato tools.
The Scimitar Elite Wireless SE stands out when side buttons need to do more than trigger in-game commands. Stream Deck integration gives it a useful advantage for creators, while the sensor and wireless options keep it suitable for regular MMO and MOBA play.
Maximum MMO Control – UtechSmart Venus Pro
If you want a gaming mouse with side buttons for complex MMO hotkeys, the UtechSmart Venus Pro provides 12 thumb-accessible buttons, extensive remapping, and a high 16,400 DPI ceiling. Its wired connection and adjustable weights make it suited to players who prioritize customization and precise control.
Best For: MMO players who want many programmable inputs, profile switching, and adjustable handling in a right-handed wired mouse.
Pros:
- 12 side buttons and 19 total buttons support extensive keybinds and macros.
- Offers up to 16,400 DPI, onboard sensitivity controls, and five custom profiles.
- Adjustable weight system, textured ergonomic shell, thumb rest, and Teflon feet support controlled handling.
- RGB lighting includes multiple colors and configurable profile modes.
Cons:
- The wired design is less flexible than a wireless mouse.
- Its large number of buttons may take time to learn and configure.
- Software support is listed for Windows systems.
The Venus Pro is a strong choice when MMO bindings matter more than a minimalist layout. Its adjustable weight and angled side buttons add practical control, while the corded design keeps setup straightforward.
Flexible Wireless MMO Play – Redragon M913 Wireless MMO Mouse
The Redragon M913 is a gaming mouse with side buttons that combines 12 thumb controls with both 2.4 GHz wireless and USB-C wired modes. It also offers a Pixart 3335 optical sensor, customizable buttons, and battery life rated for up to 45 hours with the backlight on.
Best For: MMO players who want wireless freedom without giving up wired operation, extensive remapping, or onboard DPI switching.
Pros:
- Dual wireless and USB-C wired connectivity suits different setups.
- 12 side buttons and 16 total programmable buttons support detailed keybinding.
- Five onboard DPI levels range from 1,000 to 16,000, with finer software adjustment available.
- Battery life is rated at 45 hours with backlighting on and up to 80 hours in eco mode.
Cons:
- Wireless battery life decreases when RGB backlighting is enabled.
- The right-handed design may not suit left-handed users.
- Its numerous buttons can feel less immediate until customized to your preferences.
The M913 is the most flexible option here for switching between wireless and wired play. It is particularly compelling for MMO users who want many side buttons alongside low-latency wireless performance and a rechargeable battery.
Streamlined MMO Keybinds – Redragon M811 Wired MMO Mouse
For shoppers seeking a gaming mouse with side buttons on a wired setup, the Redragon M811 offers eight dedicated MMO side buttons plus 15 programmable buttons overall. Its ergonomic right-handed shape, configurable DPI levels, and RGB lighting make it a practical choice for gaming and everyday shortcuts.
Best For: MMO and productivity users who want plentiful remappable inputs in a straightforward wired mouse.
Pros:
- Eight side buttons and 15 programmable controls provide quick access to hotkeys.
- Five DPI levels are available, with software options between 500 and 12,400 DPI.
- Ergonomic shape is designed for extended gaming or work sessions.
- Dedicated software supports keybinds, media controls, DPI settings, and RGB customization.
Cons:
- It is wired rather than wireless.
- It has fewer side buttons than the 12-button MMO models in this roundup.
- The listed default DPI levels top out at 6,200 without software adjustment.
The M811 balances MMO functionality with a less crowded side layout than a 12-button mouse. Choose it if eight side buttons cover your needs and you prefer a comfortable wired design with broad software customization.
How We Picked the Best Gaming Mouse with Side Buttons
We selected these 10 mice to cover the main buying priorities in this category: button count, programmable controls, sensor performance, connection type, comfort, software support, and overall value. The list includes simple two-button gaming mice, MMO models with dense thumb grids, and premium mice with wireless connectivity or interchangeable side panels.
Because specifications vary considerably, we considered each mouse in the context of its intended use rather than treating maximum DPI or button count as the sole measure of quality. A mouse with fewer, better-positioned buttons may be more practical for FPS play, while MMO and productivity users may benefit from a larger control array.
Quick Comparison
- Best for familiar all-purpose ergonomics: Logitech G502 Hero Wired Gaming Mouse.
- Best for extensive MMO controls: Razer Naga V3 Pro or Corsair Scimitar Elite Wireless SE.
- Best for long wireless use: Razer Naga V2 HyperSpeed.
- Best budget wireless options: Redragon M913 or the Redragon 16-button wireless model.
- Best budget wired choices: Redragon M612, M811, M908, or UtechSmart Venus Pro.
Key Buying Factors for a Gaming Mouse with Side Buttons
Button Layout and Count
Decide how many thumb controls you can use accurately. Two side buttons are usually enough for FPS games and general shortcuts. A 6-, 8-, or 12-button grid is better suited to MMO rotations, MOBA commands, software shortcuts, and complex macros, but it can feel crowded until you build muscle memory.
Shape, Size, and Grip
Check the mouse dimensions and weight against your hand and grip style. Ergonomic right-handed designs can provide palm support, while lighter or narrower models may suit claw and fingertip grips. Button placement matters as much as the total number: controls should be reachable without shifting your aim.
Wired or Wireless Connectivity
Wired mice avoid charging and typically cost less. Wireless models offer a cleaner desk and greater movement freedom, but confirm battery life, charging options, wireless modes, and whether performance remains consistent when the battery is low.
Sensor and Software
High DPI numbers are less important than reliable tracking and adjustable sensitivity. Look for onboard profiles, remapping software, macro support, RGB controls, and compatibility with your operating system. Check whether the software is required for advanced functions.
Who Should Buy Which Gaming Mouse with Side Buttons?
Choose a straightforward two-button model if you mainly play shooters or want a familiar mouse with a few convenient shortcuts. MMO players who bind skills, items, and movement commands should prioritize a dedicated thumb grid, while competitive players may prefer fewer buttons, lower weight, and an uncluttered shape.
Wireless models are a strong choice for flexible setups, laptop use, and cable-free desks. Wired mice make more sense for buyers who want maximum value, uninterrupted sessions, and no battery maintenance. If you are unsure, prioritize comfort and reachable controls first; a mouse that fits your hand will usually improve performance more than an extreme DPI rating.